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2010.03.31 - Randy Trumbower - Neural contributions of limb use following CNS injury

  • Wants to translate basic science to clinical pertaining to restoration of limb function
  • Neural structures -> mechanisms -> limb functions -> interventions -> Neural structures
  • Spinal mechanisms - stretch reflexes and Ia afferents
    • What structure controls reflexes?
  • Stroke patients' reflexes
    • short latency exaggerated
    • long latency attenuated
  • Perturbation applied: admittance/displacement controlled
  • Paretic and non-paretic arms both have missing long-latency reflex in stroke
  • Need a link between abnormal reflexes and whole limb impairment
    • Flexion: shoulder up and hand toward mouth
    • Extension: shoulder down head away from body
  • Stroke patients required fewer patterns to recreate EMG
  • Similar activation patterns but one pattern is used much more than the others in stroke
  • Intermittent Hypoxia
    • Use it to increase sensorimotor performance
    • Potential mechanism is that it helps aid plasticity
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