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2010.03.24 - Art English - Motor neuron synapses decay w/o neurotrophins

Synaptic stripping of motorneurons
  • Synapses strip off of muscles only when axons are cut.  Afferents being cut or TTX blocking does not cause the synaptic stripping.
  • Stripping is blocked by neurotrophins.
  • Cutting nerve to medial gastrocnemeus causes stripping on gastroc and soleus.  NT-3 blocked synaptic stripping best out of the neurotrophins.
  • Treadmill training enhances axon regeneration, reduces stripping and also increases BDNF and NT-4/5